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Ivermectin

25 08, 2021

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

August 25, 2021|Ivermectin, Research, World|

Conclusions:

Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the […]

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20 08, 2021

Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice

August 20, 2021|Ivermectin, Research|

Abstract

Objective and design: To investigate whether ivermectin, a semi-synthetic derivative of a family of macrocyclic lactones could inhibit lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro.

Materials and methods: C57BL/6 mice were administered ivermectin (or saline) orally and challenged intraperitoneally with LPS at a […]

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20 08, 2021

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

August 20, 2021|Ivermectin, Research|

Abstract

Background:

Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.

Areas of uncertainty:

We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people […]

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22 06, 2021

The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article

June 22, 2021|Ivermectin, Research, World|

Considering the urgency of the ongoing COVID-19 pandemic, detection of various new mutant strains and future potential re-emergence of novel coronaviruses, repurposing of approved drugs such as Ivermectin could be worthy of attention. This evidence-based review article aims to discuss the mechanism of action of ivermectin against SARS-CoV-2 and summarizing the available literature over the […]

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19 04, 2021

Ivermectin Wins in Court Again: For Human Rights

April 19, 2021|Ivermectin, Law, World|

One dose of Ivermectin was all it took to get 81-year-old John Swanson off the ventilator. John’s wife Sandra could not believe it. His story is remarkably similar to other cases of patients who were on their way out with advanced COVID-19 but saved when Ivermectin was added.

Ralph Lorigo […]

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17 02, 2021

Head of Tokyo Medical Association recommends use of Ivermectin for coronavirus patients and their caregivers

February 17, 2021|Doctors, Ivermectin, World|

In Japan, the country where Ivermectin was invented and merited a Nobel Prize in Medicine and Physiology for its creator, Professor Satoshi Omura, a very important member of the medical establishment has come out recommending Ivermectin for use on patients with the coronavirus, as a therapy, and for their caregivers.  The Nihon Keizai Shimbun (Japan’s version […]

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20 10, 2020

Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2

October 20, 2020|Ivermectin, Research|

Abstract

Background/aim: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One drug that has attracted interest is the antiparasitic compound ivermectin, a macrocyclic lactone derived from the bacterium Streptomyces avermitilis. We carried out a docking study to determine if ivermectin […]

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